Rosenberg N, Garnier R, Rousselin X et al, Clinical and socio-professional fate of isocyanate-induced asthma, Clin Allergy, 1987;17:55-61,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

50% of those removed from exposure remained symptomatic 19 months after cessation of exposure versus all those who remained in same job with safer conditions/those relocated in same place of work. Of the 20 subjects removed from exposure, 10/20 were asymptomatic - appeared to be younger and to have shorter durations of total and symptomatic exposures. Even modest re-exposure allows the allergic process to continue. In those given new jobs in which the sensitising agent was nearly always absent, excellent clinical and functional improvement was observed. Therefore quality of new work site seems to play a role in evolution of isocyanate-induced asthma. Prognostic factors include duration of symptoms, length of exposure to the sensitiser and bronchial responsiveness at diagnosis.

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