Redlich CA, Stowe MH, Wisnewski AV et al, Subclinical Immunologic And Physiologic Responses In Hexamethylene Di-isocyanate - Exposed Auto Body Shop Workers, Am J Ind Med, 2001;39:587-597,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to characterize effects of di-isocyanate exposures on auto body shop workers. No overt cases of clinically apparent di-isocyanate asthma were identified based on spirometry, methacholine challenge, peak flows, and symptoms. Hexamethylene di-isocyanate (HDI)-specific lymphocyte proliferation was present in 30% and HDI-specific IgG in 34% of workers, but they were not associated. HDI-specific IgE was detected in 2 workers. HDI-specific lymphocyte proliferation, increased methacholine responsiveness, and symptoms of chest tightness/ shortness of breath were more common in most heavily HDI-exposed workers. Findings demonstrate the presence of HDI-specific immune responses in a large proportion of healthy HDI-exposed workers.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2+ Skin prick testing and blood sampling of exposed workers to conduct immunological tests is feasible in the workplace.

** 3 Acceptable peak flow series can be obtained in around two thirds of those in whom a diagnosis of occupational asthma is being considered.

Non Bohrf Information

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