Piirila PL, Nordman H, Keskinen HM et al, Long-term follow-up of hexamethylene di-isocyanate-diphenylmethane di-isocyanate-, and toluene di-isocyanate-induced asthma, Am J Respir Crit Care Med, 2000;162:516-522,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study carried out on average 10 years after diagnosis. Patients with IgE-mediated asthma had significantly better prognosis than IgE negative patients. It proved to be partly due to shorter exposure and symptomatic periods before diagnosis. Hexamethylene di-isocyanate (HDI)-induced asthma was associated with a better outcome than diphenylmethane di-isocyanate (MDI) and toluene di-isocyanate (TDI)-induced asthma. Those who continued in their primary work place did not report more symptoms than those working in new work places. Early diagnosis and adequate medical surveillance, including active treatment and swift vocational rehabilitation, are equally essential for the patient's overall prognosis. No association between persistence of symptoms or need of medication with duration of exposure, duration of symptoms before diagnosis or the latency period.

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