Baur X, Huber H, Degens PO, Allmers H, Ammon J, Relation Between Occupational Asthma Case History, Bronchial Methachlorine Challenge, And Specific Challenge Test In Patients With Suspected Occupational Asthma, Am J Ind Med, 1998;33:114-122,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Methacholine challenge (MC) was performed in 229 subjects with suspected occupational asthma. They were also subjected to specific challenge tests, questionnaire, and interviewed by an experienced physician. Study aimed to investigate whether MC and/or occupational asthma case history are reliable predictors of specific challenge test outcomes. MC results are only moderately associated with workplace-related asthma case histories whereas positive outcomes of challenges with occupational agents are well correlated with positive MC results plus occupational asthma case histories. Authors conclude that in most cases, occupational asthma is combined with bronchial hyper-responsiveness (BHR) and workplace-related asthmatic symptoms. In subjects with a positive occupational asthma case history, a negative MC test result can almost rule out a positive specific challenge test result. Hence, the MC test can reduce performance of the laborious specific challenge test.

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