Park HS, Nahm DH, Prognostic factors for toluene di-isocyanate-induced occupational asthma after removal from exposure, Clin Exp Allergy, 1997;27:1145-1150,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Subjects were given anti-asthmatics, recommended to avoid exposure to Toluene di-isocyanate (TDI), and were monitored for 2 years (mean follow-up 12 months). 17/35 recovered completely, 11 showed significant improvement and 7 remained stable. No effect of age or exposure duration or specific IGE was noted. Favourable prognosis was associated with short duration of asthmatic symptoms before diagnosis, immediate cessation of exposure after diagnosis, milder degree of airway hyper-responsiveness, and the presence of specific IgE antibodies to TDI-human serum albumin conjugate.

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