Paggiaro PL, Loi AM, Rossi O et al, Follow-up study of patients with respiratory disease due to toluene di-isocyanate (TDI), Clin Allergy, 1984;14:463-469,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

27 asthmatic and 20 non-asthmatic subjects were followed up 2 years after first examination. 15/27 asthmatics who continued exposure showed significant decrease in FEV1 and bronchial hyper-responsiveness and symptoms of chronic bronchitis. Non-asthmatics showed significant decrease of pulmonary function without changes in bronchial hyper-responsiveness. Conclude that stopping exposure to Toluene di-isocyanate (TDI) frequently did not produce an improvement of the TDI bronchial asthma, but in many cases symptoms of bronchoconstriction and bronchial hyper-responsiveness persist or may get worse. On the other hand, persistence of the occupational exposure causes a more rapid decline of the respiratory function.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

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