McSharry C, Anderson K, McKay IC, Colloff MJ, Feyerabend C, Wilson, RB, Wilkinson PC, The IgE and IgG antibody responses to aerosols of Nephrops norvegicus (prawn) antigens: the association with clinical hypersensitivity and with cigarette smoking., Clin Exp Immunol, 1994;97:499-504,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Raised levels of serum IgE antibodies to prawn antigens were found in 15/26 seafood factory process workers with respiratory symptoms and in 1/26 case-matched asymptomatic controls. Raised IgG antibody titres against the same antigens were found in 18 subjects in each symptom grouping. The prawn-specific IgE antibody response was significantly associated with atopy and with a history of cigarette smoking. Non-atopic non-smokers were unlikely to become sensitized. The titre of the prawn-specific IgE antibody correlated with the duration of exposure and with the duration of symptoms. IgE antibody was produced mainly by smokers, whereas IgG antibody was the predominant antibody produced by non-smokers.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

Non Bohrf Information

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