Marabini A, Brugnami G, Curradi F et al, Response to bronchoprovocation test and outcome of occupational asthma. A follow-up study of subjects with TDI asthma, Med del Lavoro, 1994;85:134-141,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

In the group of patients with Toluene di-isocyanate (TDI) related asthma, there was a clear tendency for the asthma to become chronic, regardless of continuation of exposure. Average follow-up period was 6.8 years (SD 0.6). 70% of subjects were 'no longer exposed' to TDI and 14.3% of this group were asymptomatic. No differences observed in symptom prevalence or lung function between exposed or non-exposed subjects. Significant decreases observed in FVC in both groups at follow-up.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

Non Bohrf Information

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