Mapp CE, Beghe B, Balboni A et al, Association between hla genes and susceptibility to toluene di-isocyanate-induced asthma, Clin Exp Allergy, 2000;30:651-656,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Frequencies of DQA1*0104 and DQB1*0503 were significantly increased in asthmatics compared with asymptomatic controls. DQA1*0101 and DQB1*0501 were significantly increased in asymptomatic controls. No significant difference was found in distribution of DRB1 alleles between asthmatics and controls. Results suggest role for HLA class II genes in conferring susceptibility or resistance to occupational asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2- Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

Non Bohrf Information

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