Mapp CE, Fryer AA, DeMarzo N et al, Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates, J Allergy Clin Immunol, 2002;109:867-872,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

The phenotype of the disease was characterized by using detailed clinical history, lung volumes, airway responsiveness to methacholine, and airway responsiveness to toluene di-isocyanate (TDI). In patients exposed to TDI for 10 or more years, the frequency of the GSTP1 Val/Val genotype was lower in subjects who had asthma (odds ratio, 0.23). Similarly, the frequency of this genotype was significantly lower in subjects with evidence of moderate-to-severe airway hyper-responsiveness to methacholine compared with the frequency in subjects with normal or mild hyper-responsiveness. Data suggest that homozygosity for the GSTP1*Val allele confers protection against TDI-induced asthma and airway hyper-responsiveness. This view is supported by the finding that the protective effect increases in proportion to the duration of exposure to TDI.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2- Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

Non Bohrf Information

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