Mapp CE, Beghe B, Balboni A et al, Persistent asthma due to isocyanates : A follow-up study of subjects with occupational asthma due to toluene di-isocyanate (TDI), Am Rev Respir Dis, 1988;137:1326-1329,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Subjects with occupational asthma due to Toluene di-isocyanate (TDI) exposure were examined. Average duration of exposure to isocyanates ranged 3-41 years, Average follow-up interval of 10 months. 62.9% of subjects showed positive TDI inhalation challenge even following removal from exposure. 22% lost sensitisation to TDI following removal from exposure. Respiratory symptoms, isocyanates sensitisation, and airway hyper-responsiveness to methacholine may persist after removal from occupational exposure to TDI. The type of asthmatic reaction and the severity of the reaction may be important factors for the persistence or the remission of the disease.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

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