Liss GM, Bernstein D, Genesove L et al, Assessment of risk factors for IgE-mediated sensitisation to tetrachlorophthalic anhydride, J Allergy Clin Immunol, 1993;92:237-247,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

The prevalence of specific IgE was highest in the mold and intermittent groups (54%), in comparison with the coil assembly (25%) and office (0%) groups. Since ventilation was installed and tetrachlorophthalic anhydride (TCPA) exposures reduced to less than 0.1 mg/m3, there was a marked decrease in symptoms and no new cases of occupational asthma among newly hired workers at the plant. A high prevalence of respiratory symptoms was reported. After adjusting for smoking status the differences between exposure groups was not significant. Associations were found between the prevalence of TCPA-specific IgE responses and both exposure status and duration of employment. There was a higher prevalence of sensitisation among those who have never smoked and former smokers.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

*** 2++ Reducing airborne exposure reduces the number of workers who become sensitised and who develop occupational asthma.

Non Bohrf Information

This page is showing the information from the BOHRF occupational asthma guidelines for this reference. To see additional information, including opinions left by users of this website please view the full reference. This page allows users to comment on the reference and suggest it as evidence for questions. These may be the existing questions from the Bohrf occupational asthma guidelines or questions that have been put forward by users of this website.

Oasys and occupational asthma smoke logo