Lemiere C, Cartier A, Dolovich J et al, Outcome of specific bronchial responsiveness to occupational agents after removal from exposure, Am J Respir Crit Care Med, 1996;154:329-333,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

After removal from exposure to the offending agent (mean duration of exposure after onset of symptoms before removal 6 years, follow up assessments on average 3.3 years after removal from exposure), 60% of subjects showed a decrease but a persistence of specific bronchial responsiveness to high and low molecular weight agents. 63% of subjects with occupational asthma to high molecular weight agents had a decrease in specific IgE levels. Significant improvement in non-specific bronchial reactivity (NSBR) in 47% of subjects was observed and all subjects reported symptomatic improvement - 2 were asymptomatic.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

Non Bohrf Information

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