Occupational Asthma Reference
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Vandenplas O, Delwiche J-P, Auverdin J, Caroyer J-M, Binard-Van Cangh F,
Asthma to tetramethrin,
Allergy,
2000;55:417-418,
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Keywords: Chrysanthemum cinerariifolium, new cause, Belgium, pyrethrum, challenge, NSBR, case report, new cause
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Abstract
PYRETHRUM is extracted from the flowers of Chrysanthemum cinerariifolium (botanic family of Compositae). The active components of pyrethrum are esters of chrisanthemic and pyrethric acids (i.e.pyrethrins, cinerins, and jasmolins), which are collectively referred to as pyrethrins. Pyrethrum and pyrethrins have been used since the early 19th century for control of
indoor insect pests as well as for direct application to man and animals. Synthetic analogs, termed the pyrethroids (e.g. permethrin, allethrin, tetramethrin, and permethrin), have been developed to enhance insecticidal activity and photostability.
The patient sprayed insecticides. Histamine PC20 was 0.125 mg/ml. After a control challenge with a paint diluent, the subject sprayed an insecticide
formulation containing 0.2% tetramethrin and 0.1% fenitrothion, which resulted in a dual asthmatic reaction
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